Past Highlights

Student Highlights 2015

Congratulations to BCDB Student Emily Rye Weikum for being awarded a Travel award to attend the ASBMB Meeting!

Congratulations to BCDB Student Kevin Morris who was awarded an NIH NRSA Predoctoral Fellowship!

5F31GM112418-03: “Defining the neuronal function of the polyadeonsine RNA-Binding protein ZC3H14”

Congratulations to BCDB Student Matthew Randolph for publishing a first author review in Frontiers in Aging & Neuorscience!

Randolph ME, Pavlath GK. (2015). A muscle stem cell for every muscle: variability of satellite cell biology among different muscle groups. Front Aging Neurosci. 7:190. doi: 10.3389/fnagi.2015.00190. PMID: 26500547

Congratulations to BCDB Student Marc Schureck for publishing a paper in PNAS!

Schureck MA, Dunkle JA, Maehigashi T, Miles SJ, Dunham CM. (2015). Defining the mRNA recognition signature of a bacterial toxin protein. Proc Natl Acad Sci U S A. 112(45):13862-7. doi: 10.1073/pnas.1512959112. PMID: 26508639

Congratulations to BCDB Student Kevin Van Bortle for publishing a first author paper in RNA!

Van Bortle K, Nichols MH, Ramos E, Corces VG. (2015). Integrated tRNA, transcript, and protein profiles in response to steroid hormone signaling. RNA. 21(10):1807-17. doi: 10.1261/rna.052126.115. PMID: 26289344

Congratulations to BCDB Student Nick Bauer for publishing a first author review in Traffic!

Bauer NC, Doetsch PW, Corbett AH. (2015). Mechanisms Regulating Protein Localization. Traffic. 16(10):1039-61. doi: 10.1111/tra.12310. PMID: 26172624

Congratulations to BCDB Student Matthew Randolph for publishing a first author paper in Stem Cells!

Randolph ME, Phillips BL, Choo HJ, Vest KE, Vera Y, Pavlath GK. (2015). Pharyngeal Satellite Cells Undergo Myogenesis Under Basal Conditions and Are Required for Pharyngeal Muscle Maintenance. Stem Cells. 33(12):3581-95. doi: 10.1002/stem.2098. PMID: 26178867

Congratulations to BCDB Student Sara Stahley for publishing a first author review in the Cell Tissue Research!

Stahley SN, Kowalczyk AP. (2015). Desmosomes in acquired disease. Cell Tissue Res. 360(3):439-56. doi: 10.1007/s00441-015-2155-2. PMID: 25795143

Congratulations to BCDB Student Callie Wigington for publishing a first author paper in Journal of Biological Chemistry!

Wigington CP, Jung J, Rye EA, Belauret SL, Philpot AM, Feng Y, Santangelo PJ, Corbett AH. (2015). Post-transcriptional regulation of programmed cell death 4 (PDCD4) mRNA by the RNA-binding proteins human antigen R (HuR) and T-cell intracellular antigen 1 (TIA1). J Biol Chem. 290(6):3468-87. doi: 10.1074/jbc.M114.631937. PMID: 25519906

Congratulations to BCDB Student Julia Omotade who was awarded an NIH NRSA Predoctoral Fellowship!

5F31NS092437-02: “The role of tropomodulin in dendritic spine development and synapse formation”

Congratulations to BCDB Student Emily Rye Weikum who was awarded an NIH NRSA Predoctoral Fellowship!

1F31GM113397-01A1: “A novel mechanism for the glucocorticoid receptor in inflammatory gene regulation"

Congratulations to BCDB Student Kevin Van Bortle for publishing a first author paper in Cell Cycle!

Van Bortle K, Peterson AJ, Takenaka N, O'Connor MB, Corces VG. (2015). CTCF-dependent co-localization of canonical Smad signaling factors at architectural protein binding sites in D. melanogaster. Cell Cycle. 14(16):2677-87. doi: 10.1080/15384101.2015.1053670. PMID: 26125535

Congratulations to BCDB Student Jarred Whitlock for publishing a co-first author paper in eLife!

Yu K*, Whitlock JM*, Lee K, Ortlund EA, Cui YY and Hartzell HC. (2015). Identification of a lipid scrambling domain in ANO6/TMEM16F. eLife. Jun 9;4:e06901. doi: 10.7554/eLife.06901. *Co-first authors.

Congratulations to BCDB Student Nick Bauer for publishing a first author review in Nucleic Acids Research!

Bauer NC, Corbett AH, Doetsch PW. (2015). The current state of eukaryotic DNA base damage and repair. Nucleic Acids Res. 43(21):10083-101. doi: 10.1093/nar/gkv1136. PMID: 26519467

Student Highlights 2014

Congratulations to BCDB Student Laura Newman for publishing a paper in PLoS One!

Newman LE, Zhou CJ, Mudigonda S, Mattheyses AL, Paradies E, Marobbio CM, Kahn RA. (2014). The ARL2 GTPase is required for mitochondrial morphology, motility, and maintenance of ATP levels. 9(6):e99270. doi: 10.1371/journal.pone.0099270. PMID: 24911211.

Congratulations to BCDB Student Paul Donlin-Asp who was selected to attend Young Researcher Attendee of the 64th Annual Lindau Nobel Laurate Meeting, attendance sponsored by the Acola Foundation.

Congratulations to BCDB Student Laura Newman who was awarded an NIH NRSA Predoctoral Fellowship!

5F31GM111047-02: “Regulation of Mitochondrial Function by Arl2 and its putative effector Elmod2”

Congratulations to BCDB Student Josh Francis who was awarded an NIH NRSA Predoctoral Fellowship!

5F31CA189672-03: “A novel mechanism of GTPase regulation: Arl2 interaction with TBCD”

Congratulations to BCDB Student Kevin Van Bortle for publishing a first author paper in Genome Biology!

Van Bortle K, Nichols MH, Li L, Ong CT, Takenaka N, Qin ZS, Corces VG. (2014). Insulator function and topological domain border strength scale with architectural protein occupancy. Genome Biol. 15(6):R82. doi: 10.1186/gb-2014-15-5-r82. PMID: 24981874

Congratulations to BCDB Student Crys Fagan for publishing a first author paper in RNA!

Fagan CE, Maehigashi T, Dunkle JA, Miles SJ, Dunham CM. (2014). Structural insights into translational recoding by frameshift suppressor tRNASufJ. RNA. 20(12):1944-54. doi: 10.1261/rna.046953.114. PMID: 25352689

Congratulations to BCDB Student Matthew Randolph for publishing a first author paper in Journal of Physiology!

Randolph ME, Luo Q, Ho J, Vest KE, Sokoloff AJ, Pavlath GK. (2014). Ageing and muscular dystrophy differentially affect murine pharyngeal muscles in a region-dependent manner. J Physiol. 592(23):5301-15. doi: 10.1113/jphysiol.2014.280420. PMID: 25326455

Congratulations to BCDB Student Callie Wigington for publishing a first author review in Wiley Interdisciplnary Reviews of RNA!

Wigington CP, Williams KR, Meers MP, Bassell GJ, Corbett AH. (2014). Poly(A) RNA-binding proteins and polyadenosine RNA: new members and novel functions. Wiley Interdiscip Rev RNA. 5(5):601-22. doi: 10.1002/wrna.1233. PMID: 24789627

Congratulations to BCDB Student Rasagna Viswandha for publishing a first author paper in Cytoskeleton!

Viswanadha R, Hunter EL, Yamamoto R, Wirschell M, Alford LM, Dutcher SK, Sale WS. (2014). The ciliary inner dynein arm, I1 dynein, is assembled in the cytoplasm and transported by IFT before axonemal docking. Cytoskeleton (Hoboken). 71(10):573-86. doi: 10.1002/cm.21192. PMID: 25252184

Congratulations to BCDB Student Chelsey Ruppersburg for publishing a paper in Molecular Biology of the Cell!

Ruppersburg CC, Hartzell HC. (2014). The Ca2+-activated Cl- channel ANO1/TMEM16A regulates primary ciliogenesis. Mol Biol Cell. 25(11):1793-807. doi: 10.1091/mbc.E13-10-0599. PMID: 24694595

Congratulations to BCDB Student Emily Kuiper who published a first author paper in Journal of Biological Chemistry!

Kuiper EG, Conn GL. (2014). Binding induced RNA conformational changes control substrate recognition and catalysis by the thiostrepton resistance methyltransferase (Tsr). J Biol Chem. 289(38):26189-200. doi: 10.1074/jbc.M114.574780. PMID: 25086036

Congratulations to BCDB Student Marc Schureck for publishing a paper in Journal of Biological Chemistry!

Schureck MA, Maehigashi T, Miles SJ, Marquez J, Cho SE, Erdman R, Dunham CM. (2014). Structure of the Proteus vulgaris HigB-(HigA)2-HigB toxin-antitoxin complex. J Biol Chem. 289(2):1060-70. doi: 10.1074/jbc.M113.512095. PMID: 24257752

Congratulations to BCDB Student Mariana Mandler for publishing a paper in Nucleic Acids Research!

Mandler MD, Ku L, Feng Y. (2014). A cytoplasmic quaking I isoform regulates the hnRNP F/H-dependent alternative splicing pathway in myelinating glia. Nucleic Acids Res. 42(11):7319-29. doi: 10.1093/nar/gku353. PMID: 24792162

Congratulations to BCDB Student Alicia Cutler who was awarded an NIH NRSA Predoctoral Fellowship!

5F31AR067645-02: "Interplay between nuclear import and transcriptional activity during myogenesis"

Congratulations to BCDB Student Jessie Hwang for publishing a first author review in the International Journal of Biochemistry & Cell Biology!

Hwang J, Pallas DC. (2014). STRIPAK complexes: structure, biological function, and involvement in human diseases. Int J Biochem Cell Biol. 47:118-48. doi: 10.1016/j.biocel.2013.11.021. PMID: 24333164

Congratulations to BCDB Student Emily Rye Weikum for being awarded the Best Poster Prize at the University of Alabama Birmingham’s Structural Biology Symposium!

Congratulations to BCDB Student Sara Stahley for publishing a first author paper in PLoS One!

Stahley SN, Saito M, Faundez V, Koval M, Mattheyses AL, Kowalczyk AP. (2014). Desmosome assembly and disassembly are membrane raft-dependent. PLoS One. 9(1):e87809. doi: 10.1371/journal.pone.0087809. PMID: 24498201

Student Highlights 2013

Congratulations to BCDB Student Danny Barron who was awarded an NIH NRSA Predoctoral Fellowship!

1F30CA177156-03: “Dynein light chain 1 (DLC1) regulates growth in Drosophila melanogaster”

Congratulations to BCDB Student Jadiel Wasson for publishing a first author review in Briefings in Functional Genomics!

Wasson JA, Ruppersburg CC, Katz DJ. (2013). Restoring totipotency through epigenetic reprogramming. Brief Funct Genomics 12(2):118-28. doi: 10.1093/bfgp/els042. PMID:23117862

Congratulations to BCDB Student Jen Colucci for publishing a first author paper in PLoS One!

Colucci JK, Ortlund EA. (2013). X-ray crystal structure of the ancestral 3-ketosteroid receptor-progesterone-mifepristone complex shows mifepristone bound at the coactivator binding interface. PLoS One 8(11):e80761. doi: 10.1371/journal.pone.0080761. PMID: 24260475

Congratulations to BCDB Student John Lattier for publishing a first author paper in Clinical and Experimental Metastasis!

Lattier JM, Yang H, Crawford S, Grossniklaus HE. (2013). Host pigment epithelium-derived factor (PEDF) prevents progression of liver metastasis in a mouse model of uveal melanoma. Clin Exp Metastasis. 30(8):969-76. doi: 10.1007/s10585-013-9596-3. PMID: 23793989

Congratulations to BCDB Student Crys Fagan for publishing a first author paper in PNAS!

Fagan CE, Dunkle JA, Maehigashi T, Dang MN, Devaraj A, Miles SJ, Qin D, Fredrick K, Dunham CM. (2013). Reorganization of an intersubunit bridge induced by disparate 16S ribosomal ambiguity mutations mimics an EF-Tu-bound state. Proc Natl Acad Sci U S A. 110(24):9716-21. doi: 10.1073/pnas.1301585110. PMID: 23630274

Congratulations to BCDB Student Marc Schureck who was awarded an NIH NRSA Predoctoral Fellowship!

5F31GM108351-02: “Mechanism of HigB-mediated ribosome-dependent mRNA degradation”

Congratulations to BCDB Student Megan Allen for publishing a first author paper in PLoS One!

Allen M, Bird C, Feng W, Liu G, Li W, Perrone-Bizzozero NI, Feng Y. (2013). HuD promotes BDNF expression in brain neurons via selective stabilization of the BDNF long 3'UTR mRNA. PLoS One. 8(1):e55718. doi: 10.1371/journal.pone.0055718. PMID: 23383270

Congratulations to BCDB Student Kevin Van Bortle for publishing a first author review in Cell!

Van Bortle K, Corces VG. (2013). Spinning the web of cell fate. Cell. 14;152(6):1213-7. doi: 10.1016/j.cell.2013.02.052. PMID: 23498930

Congratulations to BCDB Student Nick Bauer for publishing a first author paper in Traffic!

Bauer NC, Corbett AH, Doetsch PW. (2013). Automated quantification of the subcellular localization of multicompartment proteins via Q-SCAn. Traffic. 14(12):1200-8. doi: 10.1111/tra.12118. PMID: 24034606

Congratulations to BCDB Student Robert Rankin for publishing a first author paper in Journal of Biological Chemistry!

Rankin CR, Hilgarth RS, Leoni G, Kwon M, Den Beste KA, Parkos CA, Nusrat A. (2013). Annexin A2 regulates β1 integrin internalization and intestinal epithelial cell migration. J Biol Chem. 288(21):15229-39. doi: 10.1074/jbc.M112.440909. PMID: 23558678

Congratulations to BCDB Student Kevin Van Bortle for publishing a first author review in Current Opinion in Genetics & Development!

Van Bortle K, Corces VG. (2013). The role of chromatin insulators in nuclear architecture and genome function. Curr Opin Genet Dev. 23(2):212-8. doi: 10.1016/j.gde.2012.11.003. PMID: 23298659

Congratulations to BCDB Student Jen Colucci for publishing a first author paper in Acta Crystallographica!

Colucci JK, Ortlund EA. (2013). Expression, purification and crystallization of the ancestral androgen receptor-DHT complex. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Sep;69(Pt 9):994-6. doi: 10.1107/S1744309113018745. PMID: 23989146

Congratulations to BCDB Student Paul Donlin-Asp who was awarded an NIH NRSA Predoctoral Fellowship!

F31NS084730-01: “The survival of motor neuron protein in axonal mRNA localization”

Student Highlights 2012

Congratulations to BCDB Student Kevin Van Bortle for publishing a first author review in Transcription!

Van Bortle K, Corces VG. (2012). tDNA insulators and the emerging role of TFIIIC in genome organization. Transcription. 3(6):277-84. doi: 10.4161/trns.21579. PMID: 22889843

Congratulations to BCDB Student Mike East for publishing a first author paper in Journal of Biological Chemistry!

East MP, Bowzard JB, Dacks JB, Kahn RA. (2012). ELMO domains, evolutionary and functional characterization of a novel GTPase-activating protein (GAP) domain for Arf protein family GTPases. J Biol Chem. 287(47):39538-53. doi: 10.1074/jbc.M112.417477. PMID: 23014990

Congratulations to BCDB Student Ben Nanes for publishing a first author paper in the Journal of Cell Biology!

Nanes BA, Chiasson-MacKenzie C, Lowery AM, Ishiyama N, Faundez V, Ikura M, Vincent PA, Kowalczyk AP. (2012). p120-catenin binding masks an endocytic signal conserved in classical cadherins. J Cell Biol. 199(2):365-80. doi: 10.1083/jcb.201205029. PMID: 23071156

Congratulations to BCDB Student Katie Williams who was awarded an NIH NRSA Predoctoral Fellowship!

5F31MH095266-03: “Modulation of RhoA Signaling by the mRNA binding protein hnRNPQ1”

Congratulations to BCDB Student Kevin Van Bortle for publishing a first author paper in Genome Biology!

Van Bortle K, Ramos E, Takenaka N, Yang J, Wahi JE, Corces VG. (2012). Drosophila CTCF tandemly aligns with other insulator proteins at the borders of H3K27me3 domains. Genome Res. 22(11):2176-87. doi: 10.1101/gr.136788.111. PMID: 22722341

Congratulations to BCDB Student Sharon Soucek for publishing a first author review in Biochimica et Biophysica Acta!

Soucek S, Corbett AH, Fasken MB. (2012). The long and the short of it: the role of the zinc finger polyadenosine RNA binding protein, Nab2, in control of poly(A) tail length. Biochim Biophys Acta. 1819(6):546-54. doi: 10.1016/j.bbagrm.2012.03.006. PMID: 22484098.

Congratulations to BCDB Student Ben Nanes who was awarded an NIH NRSA Predoctoral Fellowship!

5F30HL110447-04: “Regulation of Endothelial Adhesion by VE-Cadherin endocytosis”

Congratulations to BCDB Student Kevin Van Bortle for publishing a first author review in Annual Reviews in Cell & Developmental Biology!

Van Bortle K, Corces VG. (2012). Nuclear organization and genome function. Annu Rev Cell Dev Biol. 28:163-87. doi: 10.1146/annurev-cellbio-101011-155824. PMID: 22905954

Student Highlights 2011

Congratulations to BCDB Student Matthew Randolph who was awarded an NIH NRSA Predoctoral Fellowship!

5F31DC012225-03: “Muscle Stem Cells in Pharyngeal Pysiology and Dysphagia”

Student Highlights 2008-2010

Congratulations to BCDB Student Mike East for publishing a first author review in Seminars in Cell & Developmental Biology!

East MP, Kahn RA. Models for the functions of Arf GAPs. (2011). Semin Cell Dev Biol. 22(1):3-9. doi: 10.1016/j.semcdb.2010.07.002. PMID: 20637885