Genetics and Genomics

expressionGenetic and Epigenetic alterations

  • This group focuses on genetic and epigenetic alterations that ultimately result in cancer initiation and progression
  • The epigenetics components of this program includes DNA methylation, and chromatin modifications leading to unregulated transcription, an important component of tumor biogenesis.  

DNA damage managing systems

  • Another major focus of this program is DNA damage managing systems, including DNA repair, and DNA damage recognition. 
  • DNA damage includes that induced by mutagens, as well as chromosome instability and aneuploidy triggered by oncogenes and tumor suppressors

Cancer genomics

  • Another focus of this program is cancer genomics, in which the changes in gene expression, DNA methylation, mutations, amplifications, and deletions are examined on a global scale to understand the mechanisms of cancer initiation and progression.