- This group concentrates on the signaling events by which cancer cells establish themselves in the host organism and form a neoplastic tissue.
- The biological mechanisms, by which cancer cells activate proliferation, overcome apoptosis, develop self-sufficiency in growth factors, evade the immune system, become invasive and metastatic, induce angiogenesis and vasculogenesis and other hallmarks of cancer are studied.
- This group uses both in vitro and in vivo model systems to study these processes that include live cell imaging, mouse xenograft models, and 3-D tissue cultures.
- In addition, cancer proteomic approaches are used to discover new mediators of disease and candidate biomarkers.
- Several groups interact closely with the drug development laboratories to identify new cancer targets that develop from their research