Winship installs state-of-the-art lattice sheet microscope

Winship Cancer Institute is one of only 15 sites worldwide to acquire and install a lattice sheet microscope, novel technology that will change the way researchers are able to visualize live cells.

Unlike conventional microscopes, lattice light sheet microscopy allows investigators to view live cells at the highest combined 4D resolution attainable (three spatial dimensions and time). The system integrates two orthoganol or perpendicular lenses that are perfectly matched. A thin sheet of light is made up of multiple beams in a lattice providing optimal illumination of the sample.  

"This microscope will allow us to probe how living cancer cells behave in real time with unprecedented spatial and temporal resolution," says Adam Marcus, PhD, director, Emory's Integrated Cellular Imaging Shared Resource. Dr. Marcus is a faculty member in the BCDB and CB programs.

Another advantage of the lattice sheet microscope is that over time it causes minimal light damage to cells.

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