Amyloid vs tau? With this AD target, no need to choose
Keqiang Ye’s lab at Emory recently published a paper in Nature Communications that offers a two for one deal in Alzheimer’s drug discovery. Dr. Ye is a faculty member in the MSP and NS programs.
Ye’s lab has been investigating an enzyme called AEP (asparagine endopeptidase), which he provocatively calls “delta secretase.” AEP is involved in processing both amyloid and tau, amyloid’s intracellular tangle-forming counterpart.
Ye’s March 2017 Nature Communications paper shows that in mice, an inhibitor of AEP has positive effects in amyloid- and tau-based Alzheimer’s models, both in terms of staving off accumulation of the toxic proteins and in protecting brain cell function.