Duel of the inflammatory master regulators: insights for drug discovery
Anti-inflammatory drugs such as dexamethasone can have harmful side effects on the skin, bones and metabolism. Structural biology research from Emory University School of Medicine has implications for the long-standing quest to separate these drugs’ benefits from their side effects.
The findings were recently published in Nature Communications (open access).
In their new paper, Eric Ortlund, PhD, and colleagues report that GR’s ability to directly bind DNA extends more broadly than previously appreciated. The first author is Will Hudson, PhD, previously an MSP graduate student with Ortlund and now a postdoctoral fellow in Rafi Ahmed’s lab at Emory Vaccine Center. Dr. Ortlund is a faculty member in the BCDB and MSP programs and Dr. Ahmed is a faculty member in the IMP and MMG programs.