Study identifies a link between antidepressant treatment resistance and inflammation

Researchers at Emory University have found that depressed patients who have not responded to multiple antidepressants exhibit evidence of increased inflammation. Findings were recently published online in the journal, Psychoneuroendocrinology.

The study shows that antidepressant treatment resistance is associated with increased inflammatory markers in patients with depression. One third of patients with depression fail to respond to currently available antidepressant medications.

“Our study suggests that measuring inflammatory markers and targeting inflammation or its downstream effects on the brain may benefit patients with multiple failed antidepressant treatment trials during their current depressive episode,” says senior author Andrew H. Miller, MD, William P. Timmie Professor of Psychiatry and Behavioral Sciences, Emory University School of Medicine. Dr. Miller is a NS faculty member.

Click here to view the full story in the Emory News Center.