The search for better animal models of Alzheimer's disease
In the past three decades, scientists’ knowledge of the biology that underlies Alzheimer’s disease has advanced tremendously. In particular, the roles of aberrant accumulation in the brain of the peptide amyloid-β, which is derived from amyloid precursor protein (APP), and microtubule-associated protein tau are now much better understood. But efforts to convert this insight into gains in the clinic have floundered. Although researchers have conducted more than 400 trials in people of potential treatments for Alzheimer’s disease, almost no drugs have been brought to the market. And despite the blame being placed on a variety of factors, one of the main sources of researchers’ concern is the animal models that are used in the initial stages of drug development.
Lary Walker, a neuroscientist at Emory University School of Medicine is mentioned in this story. He is a faculty member in the NS program.