Big Data To The Rescue Of Malaria - Why Do Some People Get Infected But Not Sick?
In recent years, the study of human immunology has been fostered by the development and rapid advances of high throughput technologies used to profile genetic, transcriptional, translational, and metabolic phenotypes during good health and disease. They have been particularly important because many of the standard manipulations using animal models are not suited for human research due ethical considerations. Therefore, methodologies such as genome-wide gene expression profiling (transcriptomics) and global metabolite screening (metabolomics) offer rich information from often limited clinical samples, such as blood.
Diverse studies have taken advantage of these methodologies to investigate host-parasite interactions in the lethal parasitic disease, Malaria. An Emory study has been mentioned in this story. Among those who conducted this study are MSP faculty member Dr. Dean P. Jones and IMP and MMG faculty member, Dr. Mary R. Galinski.