Cells in 'little brain' have distinctive metabolic needs

Cells' metabolic needs are not uniform across the brain, researchers have learned. "Knocking out" an enzyme that regulates mitochondria, cells' miniature power plants, specifically blocks the development of the mouse cerebellum more than the rest of the brain.

The results are scheduled for publication in Science Advances.

The lead author is CB faculty member Cheng-Kui Qu, MD, PhD, professor of pediatrics at Emory University School of Medicine, Winship Cancer Institute and Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta.The first author of the Science Advances paper was postdoctoral fellow Hong Zheng. Other Emory/Winship co-authors include CB and MSP faculty member Sumin Kang, PhD, CB faculty member Dolores Hambardzumyan, PhD, CB and NS faculty member Anna Kenney, PhD, and CB and MSP faculty member Jing Chen, PhD.

Click here to view the full story in the Emory News Center. The story was also featured in Lab Land - The Emory Health Sciences Research Blog and EurekAlert.