Clinical trial testing vitamin and steroid combination in sepsis patients underway at Emory

A new clinical trial at Emory University and 45 other sites around the U.S. will test a combination of vitamins and steroids in patients diagnosed with sepsis. Sepsis is caused by the body's overwhelming and life-threatening response to infection that can lead to tissue damage, organ failure and death.

The VICTAS Study, which stands for VItamin C, Thiamine (also known as vitamin B1) And Steroids in Sepsis, is a multi-center, randomized, placebo-controlled, double-blind clinical trial. 

"We are familiar with the response of each of these drugs when treating patients diagnosed with sepsis," says David Wright, MD, professor and interim chair of the Department of Emergency Medicine at Emory and VICTAS co-principal investigator. "Vitamin C is a well-known antioxidant that reduces oxidative damage in the body. Patients with sepsis are known to have thiamine deficiency, so giving replacement thiamine can help strengthen the body. And we know corticosteroids play an important role in reducing inflammation in the body. Now, we will study how patients respond when using a combination of all three." Dr. Wright is also a NS faculty member.

Researchers say there are very few side effects related to the three medications, making the combination therapy safer and more convenient to test in a large population of people.

Click here to view the full story in the Emory News Center. The story was also featured in Medical Xpress.