Sensitive to (transplant) rejection

An experimental screening method, developed by Emory and Georgia Tech scientists, aims to detect immune rejection of a transplanted organ earlier and without a biopsy needle.

The technology is based on nanoparticles that detect granzyme B enzymes produced by killer T cells. When the T cells are active, they slice up the nanoparticles, generating a fluorescent signal that is detectable in urine. The results from a mouse skin graft model were published in Nature Biomedical Engineering.

IMP faculty member Dr. Andrew Adams and co-first author and former IMP graduate student Dave Mathews are mentioned in this story.

Click here to view the full story in Lab Land - The Emory Health Sciences Research Blog.