Charles Bou-Nader, PhD
 |
(he/him) |
Assistant Professor, Department of Biochemistry, School of Medicine
Graduate Programs
- Full Member - Biochemistry, Cell and Developmental Biology
- Full Member - Genetics and Molecular Biology
Education
PhD, University Pierre and Marie Curie, 2017MS, University Pierre and Marie Curie, 2014
MS, University Lille 1, 2013
BS, Saint-Joseph University, 2011
Contact Information
Email: cbounad@emory.edu
Phone: 404-712-1756
Address:
O. Wayne Rollins Research Center, Room 4027
1510 Clifton Road NE
Atlanta, GA 30322
Our lab uses cutting edge biochemical, biophysical, and structural methods (such as cryo-EM and X-ray crystallography) to mechanistically understand how RNAs and RNP assemblies control gene expression and genomic integrity in human health and diseases. We are especially interested in defining the rules behind R-loop formation and recognition by proteins and how R-loop deregulation causes diseases such as neurological disorders, cancers, and autoimmune disorders. To tackle this gap in knowledge, we are also developing new molecular biology tools to manipulate R-loops in vitro and in vivo.
Current topics investigated in the lab include:
• The immunogenicity of nucleic acids and how R-loops contribute to immunity or viral infectivity.
• Mechanistic studies of toxic R-loops, RNAs, and other nucleic acids in neurological disorders.
• Understanding how RNA structures organize chromatin architecture and how R-loops regulate DNA-repair pathways.
Collectively, our innovative studies will not only reveal new paradigms of genomic instability and R-loop functions, but will also create new methodologies for other researchers to study R-loops more broadly and build the foundation to design new therapeutics to extend the healthy and active years of life.
Current topics investigated in the lab include:
• The immunogenicity of nucleic acids and how R-loops contribute to immunity or viral infectivity.
• Mechanistic studies of toxic R-loops, RNAs, and other nucleic acids in neurological disorders.
• Understanding how RNA structures organize chromatin architecture and how R-loops regulate DNA-repair pathways.
Collectively, our innovative studies will not only reveal new paradigms of genomic instability and R-loop functions, but will also create new methodologies for other researchers to study R-loops more broadly and build the foundation to design new therapeutics to extend the healthy and active years of life.
Atlanta Society of Mentors (ASOM), 2025
Maria Andrade
Genetics and Molecular Biology
Entrance Year: 2024
Alexandra Furney (she/her)
Biochemistry, Cell and Developmental Biology
Entrance Year: 2024
Kiana Holland
Genetics and Molecular Biology
Entrance Year: 2023
Taylor White (she/her)
Genetics and Molecular Biology
Entrance Year: 2023
