Graeme Conn, PhD

(he/him)

Professor, Department of Biochemistry, School of Medicine

Faculty Member, Emory Antibiotic Resistance Center

Graduate Programs

Full Member - Biochemistry, Cell and Developmental Biology
Full Member - Microbiology and Molecular Genetics

Education

PhD, University of Edinburgh, 1996

Contact Information

Email: gconn@emory.edu

Phone: 404-727-5965

Address:
O. Wayne Rollins Research Center, Room 4031 1510 Clifton Road NE Atlanta, GA 30322

We use modern biochemical, biophysical, computational and structural biology (e.g. single-particle cryoEM) methods to study the structures, interactions and biological functions of biomedically important RNA and protein molecules. Current topics include mechanisms of bacterial antibiotic resistance through ribosomal RNA modification and drug efflux systems, and RNA-mediated regulation of host cell innate immune responses. In both areas, we are developing small molecule regulators of these processes and avenues to novel therapeutic interventions. Our research is also complemented by extensive interactions and collaborations with other groups at Emory and world-wide.

RNA Modification and Antibiotic Resistance

Funding Agency: NIH/ NIAID
Project Dates: 05/01/2010 to 04/30/2025

MPIMechanisms and biological functions of SPOUT methyltransferases

Funding Agency: NIH/NIGMS
Project Dates: 08/01/2017 to 07/31/2026

dsRNA regulation of the cytosolic innate immune system

Funding Agency: NIH/ NIAID
Project Dates: 03/12/2019 to 02/28/2028

Atlanta Society of Mentors (ASOM), 2017

Diversity: Inclusion in the Modern Workplace, 2021

Preventing Harassment & Discrimination: Supervisors, 2023

Enoch Ayamga (he/him)

Biochemistry, Cell and Developmental Biology

Entrance Year: 2022

Mohamed Barmada

Mohamed Barmada (he/him)

Biochemistry, Cell and Developmental Biology

Entrance Year: 2022

Mina Henes

Biochemistry, Cell and Developmental Biology

Entrance Year: 2020

Tessa Larsen (she/her)

Biochemistry, Cell and Developmental Biology

Entrance Year: 2024

Alejandro Oviedo

Alejandro Oviedo (he/him)

Biochemistry, Cell and Developmental Biology

Entrance Year: 2020

Logan Kavanaugh

Microbiology and Molecular Genetics

PhD, 2024

"Molecular basis for substrate discrimination by the RND transporter MexY of MexXY-OprM in Pseudomonas aeruginosa"

Sarah Strassler

Biochemistry, Cell and Developmental Biology

PhD, 2023

"DEFINING THE MECHANISM OF SUBSTRATE RECOGNITION BY THE TRNA METHYLTRANSFERASE TRM10"

Zane Laughlin

Biochemistry, Cell and Developmental Biology

PhD, 2022

"Mechanism of Ribosomal Subunit Recognition and Modification by the Mycobacterium tuberculosis Ribosomal RNA Methyltransferase TlyA "

Samantha Schwartz

Biochemistry, Cell and Developmental Biology

PhD, 2021

"DEFINING THE RNA SIGNATURES DETECTED BY THE INNATE IMMUNE SENSOR 2’-5’-OLIGOADENYLATE SYNTHETASE 1 (OAS1)"

Brenda Calderon

Biochemistry, Cell and Developmental Biology

PhD, 2017

"Non-coding RNA 886 is a novel regulator of viral DSRNA sensors"

Kellie Vinal

Microbiology and Molecular Genetics

PhD, 2016

"Mechanisms of pathogen-derived 16S rRNA methyltransferase NpmA target recognition and enzymatic activity"

Emily Kuiper

Biochemistry, Cell and Developmental Biology

PhD, 2016

"Structure and Function of Methyltransferases that Modify the Ribosome and Ribosome-Associated Factors"

Ginny Vachon

Microbiology and Molecular Genetics

PhD, 2015

"Modulation of host cell innate immune proteins by viral non-coding RNAs"

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