Larry Boise, PhD
Professor, Department of Hematology and Medical Oncology, School of Medicine
Professor, Department of Cell Biology, School of Medicine
Graduate Programs
- Full Member - Biochemistry, Cell and Developmental Biology
- Full Member - Cancer Biology
- Full Member - Immunology and Molecular Pathogenesis
Education
PhD, Virginia Commonwealth University, 1991Contact Information
Email: lboise@emory.edu
Phone: 404-778-4724
Address:
Winship Cancer Institute, Room C4078
1365-C Clifton Road NE
Atlanta, GA 30322
1751-001-1CE
A second interest in the lab is understanding what the intrinsic and extrinsic signals are that control myeloma cell survival, how they are regulated and can influence therapeutic response. Our focus on intrinsic signals are primarily on the BCL2 family of apoptotic regulators. We study what determines why some cells may be dependent on one family member for survival and other cells on a different family member. This can be influenced both genetic (chromosomal translocations) and epigenetic (differentiation state) of the cell. Moreover, it can also be influenced by signals from other cells in the bone marrow micro-environment such as mesenchymal derived stromal cells or cytokines (IL6). We study how these and other signals influence BCL2 dependency and cell survival and influence response to therapy. This includes modern immunotherapy such as CAR-T cells.
James Ackley
Cancer Biology
Entrance Year: 2018
Topic: Determining the role of the stromal micro-environment and mitochondrial apoptotic pathway in CAR-T function in multiple myeloma
Karan Bhatia (he/him)
Cancer Biology
Entrance Year: 2023
Topic: Modeling the evolution of drug tolerant persisters in AML.
Vero Canarte (she/her)
Cancer Biology
Entrance Year: 2020
Topic: Role of CD28/CD86 signaling in the survival of Multiple Myeloma
David Weir
Cancer Biology
PhD, 2022
"CHARACTERIZATION OF CELL DEATH IN CASP3-DEFICIENT MOUSE EMBRYONIC FIBROBLASTS"
Tyler Moser-Katz
Biochemistry, Cell and Developmental Biology
PhD, 2022
"The Role of CD86 Trafficking and Signaling on Myeloma Survival and Proliferation"
Katelyn Ponder
Cancer Biology
PhD, 2018
"Mechanism of caspase-3 activation and Mcl-1 inhibition in the regulation of apoptosis"
Jason Conage-Pough
Cancer Biology
PhD, 2018
"Characterization of Constitutive BIM Phosphorylation in Plasma Cell Malignancies"
Catherine Ann Gavile
Immunology and Molecular Pathogenesis
PhD, 2017
"The role of the CD28-CD86 signaling module in maintaining myeloma cell viability"
Shardule Shah
Immunology and Molecular Pathogenesis
PhD, 2016
"Heat Shock Factor 1 Regulation in Multiple Myeloma Pathogenesis"
Brian Gaudette
Immunology and Molecular Pathogenesis
PhD, 2014
"Characterization of cell stress pathways in normal and abnormal plasma cells"