Subra Kugathasan, MD

Subra Kugathasan, MD
(he/him)

Marcus Professor, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, School of Medicine

Professor, Department of Human Genetics, School of Medicine

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Graduate Programs

  • Full Member - Genetics and Molecular Biology
  • Full Member - Population Biology, Ecology, and Evolution

Education

MD, University of Colombo, 1985

Contact Information

Email: skugath@emory.edu

Phone: 404-727-4542

Address:
Health Sciences Research Building, Room E263 1760 Haygood Drive NE Atlanta, GA 30322

Dr. Kugathasan's research has focused on understanding the genetics and genomic advances of inflammatory bowel disease (IBD). Inflammatory bowel disease (IBD), which comprises Crohn's disease (CD) and ulcerative colitis (UC), is estimated to affect approximately 3 million Americans. IBD is a destructive, life-long, chronic inflammatory disorder that results in gastrointestinal bleeding, weight loss and poor quality of life. IBD affects all races and onset of the disease is usually in children and young adults. Familial, twin, linkage and GWAS studies suggest that IBD is highly heritable. His goal is to further extend novel genetic discoveries in IBD, in particular common and rare susceptibility variants that underlie the onset and disease outcome in IBD. Since he moved to Emory in 2008, one of his focus has been the identification of genetic and epigenetic mechanisms of IBD in diverse population (non-whites mainly African Americans). This genetic / epigenetic studies have progressed to multi-omic studies now including single-cell transcriptomics, metabolomics and . In addition, he has been investigating the immunogenetic mechanisms that underlie this chronic intestinal inflammation in children and adults with IBD.

His research interests include:

To determine and identify genetic associations in very young onset IBD in comparison to those found in older patients with adult onset disease. In particular, to identify high effect, highly penetrant but rare variants that cannot be identified by genome wide association studies.

Genome wide association studies of IBD in African Americans with IBD and the use of latest generation sequencing technologies to comprehensively ascertain variation that predispose or confer IBD risk to both African Americans and Caucasians.

To identify susceptibility and modifying through Genotype, serotype, bacteriotype and gene expression studies in carefully and prospectively identified incident cases of early onset IBD. This would lead to risk stratification and personalized medicine in IBD.

Transcriptomics including single cell RNA sequencing of human gut as part of the GUT ATLAS project

Risk stratification and personalized therapy approaches using genomic in IBD

Integrative multi-omic risk assessment at diagnosis and during disease progression in African-Americans with inflammatory bowel disease

Funding Agency: NIH
Project Dates: 09/01/2022 to 09/30/2026

Clinical, imaging, and endoscopic outcomes of children newly diagnosed with Crohn’s disease (CAMEO)

Funding Agency: NIH
Project Dates: 12/01/2022 to 11/30/2027

Population-based characterization of Metabolic Pathways to predict Pediatric Crohn's Disease Outcomes

Funding Agency: NIH
Project Dates: 08/01/2022 to 08/31/2027

Diversity: Inclusion in the Modern Workplace, 2023

Ranjit Pelia

Ranjit Pelia (he/him)

Genetics and Molecular Biology

Entrance Year: 2022

Topic: Synthetic Biology, Chromatin Engineering, ncRNAs, Transcription Factors, Epigenetic

Kalifa Shabazz

Genetics and Molecular Biology

MS, 2020

Hari Somineni

Genetics and Molecular Biology

PhD, 2019

"Biological Insights from Integrative Genetic and Epigenetic analysis of Inflammatory Bowel Disease"

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