Cancer Signal Transduction
Research in this area concentrates on the complex intracellular, cell-cell, and cell-matrix signaling networks that enable cancer cells to establish themselves within the host organism and organize into malignant neoplastic tissue. Investigators delve into the fundamental molecular mechanisms that drive the established hallmarks of cancer. This includes studying how tumor cells sustain chronic proliferation, evade apoptotic cell death signals, and achieve self-sufficiency from external growth factors.
Furthermore, this research explores how these cells successfully bypass immune surveillance, remodel their microenvironment to induce tumor vasculature, and initiate the cascade toward invasion and metastasis. By dissecting these aberrant signaling pathways, program faculty aim to identify novel therapeutic targets and overcome mechanisms of treatment resistance.
The following Cancer Biology faculty members conduct research in cancer signal transduction:
- Lawrence Boise
- Kevin Bunting
- Biplab Dasgupta
- Melissa Gilbert-Ross
- Andrew Hong
- Richard Kahn
- Sumin Kang
- Aparna Kesarwala
- Adam Marcus
- Carlos Moreno
- David Pallas
- Christopher Porter
- Maureen Powers
- CK Qu
- Lindsey Seldin
- Mala Shanmugam
- Jennifer Spangle
- Shi-Yong Sun
- Yong Teng
- Yong Wan
- David Yu
- Jindan Yu
- Chris Yun
- Jason Yustein
- Wei Zhou
