Regulation of Gene Expression

Gene regulation is the primary mechanism for adaptation and development, making it a critical site of intervention for preventing developmental disorders and oncogenesis. Faculty in this area apply genetic principles to investigate the molecular control of gene expression, including transcription factor interactions, chromatin architecture, and the mechanisms of epigenetic inheritance. Our nationally recognized Emory Integrated Genomics Core (EIGC) provides state of the art technologies, such as deep sequencing, to dissect the epigenomes of diverse model organisms. Research spans a broad range of systems including mammalian immune and visual systems, neuronal epigenetics, dosage compensation in Drosophila, and the regulation of genes involved in bacterial pathogenesis. By uncovering the fundamental mechanisms of transcriptional initiation and elongation, this work defines the frontiers of biomedical science and its application to human disease.