Jae Won Chang, PhD
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Assistant Professor, Department of Pharmacology and Chemical Biology, School of Medicine
Assistant Professor, Department of Hematology and Medical Oncology, School of Medicine
Member, Discovery and Developmental Therapeutics Research Program, Winship Cancer Institute
Graduate Programs
- Full Member - Molecular and Systems Pharmacology
Education
PhD, The Scripps Research Institute, 2013MS, Sogang University, 1999
BS, Sogang University, 1997
Contact Information
Email: jae.won.chang@emory.edu
Phone: 404-727-5939
Address:
O. Wayne Rollins Research Center, Room 5029
1510 Clifton Road NE
Atlanta, GA 30322
Large-scale profiling methods have uncovered numerous gene and protein expression changes that correlate with tumorigenesis. However, determining the relevance of these expression changes and which biochemical pathways they affect has been hindered by our incomplete understanding of the proteome and its myriad functions and modes of regulation. Activity-based profiling platforms enable both the discovery of cancer-relevant enzymes and selective pharmacological probes to perturb and characterize these proteins in tumor cells. When integrated with other large-scale profiling methods, activity-based proteomics can provide insight into the metabolic and signaling pathways that support cancer pathogenesis and illuminate new strategies for disease diagnosis and treatment. Overall goal of our lab is to understand how alterations in the function of proteins contribute to human disease and to identify individual proteins and cognate biochemical pathways that can be pharmacologically targeted for human disease. Therefore, our laboratory is mainly focused on developing of novel chemical probes for profiling poorly characterized protein activities and drugs for prevention, diagnosis, treatment, and cure of diseases like cancer.
